Tracing dynamic expansion of human NK-cell subsets by high-resolution analysis of KIR repertoires and cellular differentiation
نویسندگان
چکیده
منابع مشابه
Tracing dynamic expansion of human <fc>NK</fc>cell subsets by highresolution analysis of <fc>KIR</fc> repertoires and cellular differentiation
Natural killer (NK) cells are key cellular components of the innate immune system that act at the interface between innate and adaptive immune responses [1]. An increasing body of evidence shows that specific clones of NK cells may be expanded in vivo under the influence of viruses such as human cytomegalovirus (CMV) [2, 3]. These adaptive-like NK-cell responses have been proposed to represent ...
متن کاملMHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response.
Variegated expression of 6 inhibitory HLA class I-specific receptors on primary NK cells was studied using high-dimension flow cytometry in 58 humans to understand the structure and function of NK-cell repertoires. Sixty-four subsets expressing all possible receptor com-binations were present in each repertoire, and the frequency of receptor-null cells varied among the donors. Enhancement in mi...
متن کاملTitle: MHC class I-specific inhibitory receptors and their ligands structure diverse human NK cell repertoires towards a balance of missing-self response
Variegated expression of six inhibitory HLA class I-specific receptors on primary NK cells was studied using high-dimension flow cytometry in 58 human individuals to understand the structure and function of NK cell repertoires. Sixty-four subsets expressing all possible receptor combinations were present in each repertoire and the frequency of receptor-null cells varied amongst the donors. Enha...
متن کاملNK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs.
Human natural killer (NK) cells are functionally regulated by killer cell immunoglobulin-like receptors (KIRs) and their interactions with HLA class I molecules. As KIR expression in a given NK cell is genetically hard-wired, we hypothesized that KIR repertoire perturbations reflect expansions of unique NK-cell subsets and may be used to trace adaptation of the NK-cell compartment to virus infe...
متن کاملAnalyses of HLA-C-specific KIR repertoires in donors with group A and B haplotypes suggest a ligand-instructed model of NK cell receptor acquisition.
To determine the influence of KIR and HLA class I polymorphism on human NK cell repertoires, 32 different clonotypes representing all possible combinations of 4 inhibitory KIR and NKG2A were analyzed by multicolor flow cytometry. In donors homozygous for the common group A KIR haplotype, a significant influence of HLA-C ligands was seen: KIR repertoires were dominated by clonotypes expressing a...
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عنوان ژورنال:
دوره 44 شماره
صفحات -
تاریخ انتشار 2014